In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.

@article{Bartfeld2015InVE,
  title={In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.},
  author={Sina Bartfeld and T{\"u}lay Bayram and Marc van de Wetering and Meritxell Huch and Harry Begthel and Pekka Kujala and Robert G. J. Vries and Peter J Peters and Hans Clevers},
  journal={Gastroenterology},
  year={2015},
  volume={148 1},
  pages={126-136.e6}
}
BACKGROUND & AIMS We previously established long-term, 3-dimensional culture of organoids from mouse tissues (intestine, stomach, pancreas, and liver) and human intestine and pancreas. Here we describe conditions required for long-term 3-dimensional culture of human gastric stem cells. The technology can be applied to study the epithelial response to infection with Helicobacter pylori. METHODS We generated organoids from surgical samples of human gastric corpus. Culture conditions were… CONTINUE READING
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