In vitro expansion affects the response of chondrocytes to mechanical stimulation.

@article{Das2008InVE,
  title={In vitro expansion affects the response of chondrocytes to mechanical stimulation.},
  author={Ruud HJ Das and Holger Jahr and Jan A. N. Verhaar and Jacqueline C. van der Linden and Gerjo J. V. M. van Osch and Harrie Weinans},
  journal={Osteoarthritis and cartilage},
  year={2008},
  volume={16 3},
  pages={385-91}
}
OBJECTIVE Expansion of autologous chondrocytes is a common step in procedures for cartilage defect repair. Subsequent dedifferentiation can alter cellular response to mechanical loading, having major consequences for the cell's behavior in vivo after reimplantation. Therefore, we examined the response of primary and expanded human articular chondrocytes to mechanical loading. METHOD Primary and expanded chondrocytes were stretched at either 0.5% or 3.0% at 0.5Hz, 2h per day, for 3 days. Gene… CONTINUE READING

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