In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.

@article{Godfrey2004InVH,
  title={In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.},
  author={W. Robert Godfrey and Ying G Ge and Darrin J. Spoden and Bruce L Levine and Carl H June and Bruce R Blazar and Stephen B. Porter},
  journal={Blood},
  year={2004},
  volume={104 2},
  pages={
          453-61
        }
}
CD4(+)CD25(+) T-regulatory (Treg) cells have been shown to critically regulate self- and allograft tolerance in several model systems. Studies of human Treg cells have been restricted by the small number present in peripheral blood and their naturally hypoproliferative state. To better characterize Treg suppressor cell function, we determined methods for the isolation and expansion of these cells. Stringent magnetic microbead-based purification was required for potent suppressor cell line… CONTINUE READING

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