In vitro expanded human CD4+CD25+ regulatory T cells are potent suppressors of T-cell-mediated xenogeneic responses.

@article{Wu2008InVE,
  title={In vitro expanded human CD4+CD25+ regulatory T cells are potent suppressors of T-cell-mediated xenogeneic responses.},
  author={Jingjing Wu and Shounan Yi and Li ‐ ming Ouyang and Elvira Jim{\'e}nez and Denbigh M. Simond and Wei Wang and Yiping Wang and Wayne John Hawthorne and Philip J. O'connell},
  journal={Transplantation},
  year={2008},
  volume={85 12},
  pages={1841-8}
}
BACKGROUND Cellular rejection of xenografts is predominantly mediated by CD4 T cells. Little is known of the effectiveness of CD4CD25 T regulatory (Treg) cells at suppressing this strong T-cell mediated immune response. In this study, we evaluated the activity of fresh Treg cells and expanded Treg cells to suppress the xeno immune response in vitro. METHODS Human Treg cells were preferentially expanded by CD3/CD28 expand beads, interleukin (IL)-2, and rapamycin. Human CD4CD25 T cells were… CONTINUE READING
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