In vitro evolved non-aggregating and thermostable lipase: structural and thermodynamic investigation.

Abstract

Rational and in vitro evolutionary approaches to improve either protein stability or aggregation resistance were successful, but empirical rules for simultaneous improvement of both stability and aggregation resistance under denaturing conditions are still to be ascertained. We have created a robust variant of a lipase from Bacillus subtilis named "6B… (More)
DOI: 10.1016/j.jmb.2011.09.002

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@article{Kamal2011InVE, title={In vitro evolved non-aggregating and thermostable lipase: structural and thermodynamic investigation.}, author={Md. Zahid Kamal and Shoeb Ahmad and Trivikram Rao Molugu and Amash Vijayalakshmi and Mandar V. Deshmukh and Rajan Sankaranarayanan and Nalam Madhusudhana Rao}, journal={Journal of molecular biology}, year={2011}, volume={413 3}, pages={726-41} }