In vitro evolution suggests multiple origins for the hammerhead ribozyme

@article{SalehiAshtiani2001InVE,
  title={In vitro evolution suggests multiple origins for the hammerhead ribozyme},
  author={Kourosh Salehi-Ashtiani and Jack W. Szostak},
  journal={Nature},
  year={2001},
  volume={414},
  pages={82-84}
}
The hammerhead ribozyme was originally discovered in a group of RNAs associated with plant viruses, and has subsequently been identified in the genome of the newt (Notophthalamus viridescens), in schistosomes and in cave crickets (Dolichopoda species). The sporadic occurrence of this self-cleaving RNA motif in highly divergent organisms could be a consequence of the very early evolution of the hammerhead ribozyme, with all extant examples being descended from a single ancestral progenitor… Expand
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