In vitro evolution of RNA aptamers recognizing carcinogenic aromatic amines.

@article{Brockstedt2004InVE,
  title={In vitro evolution of RNA aptamers recognizing carcinogenic aromatic amines.},
  author={Ulrike Brockstedt and Anna Użarowska and Alexandre Montpetit and Wolfgang Pfau and Damian Labuda},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={313 4},
  pages={1004-8}
}
The modification of cellular DNA by environmental substances is thought to be a crucial event in chemical induced carcinogenesis. Among the environmental carcinogens, aromatic amines are known for the fact that they can induce several types of cancers through the formation of so-called DNA adducts. We took advantage of the potential of the SELEX method to select for highly specific RNA ligands that recognize specific genotoxic aromatic amines. The aromatic amine 4,4'-methylenedianiline (MDA… CONTINUE READING