In vitro evidence that the biological effects of platelet-rich plasma on periodontal ligament cells is not mediated solely by constituent transforming-growth factor-beta or platelet-derived growth factor.

@article{Kawase2005InVE,
  title={In vitro evidence that the biological effects of platelet-rich plasma on periodontal ligament cells is not mediated solely by constituent transforming-growth factor-beta or platelet-derived growth factor.},
  author={Tomoyuki Kawase and Kazuhiro Okuda and Yoshinori Saito and Hiromasa Yoshie},
  journal={Journal of periodontology},
  year={2005},
  volume={76 5},
  pages={760-7}
}
BACKGROUND The biological actions of platelet-rich plasma (PRP) are thought to be mediated primarily by constituent transforming-growth factor-beta1 (TGF-beta1) and platelet-derived growth factor-AB (PDGF-AB). However, we previously demonstrated that type I collagen expression in periodontal ligament (PDL) cells is acutely stimulated through fibrin clot formation produced by the fibrinogen within PRP, rather than by the known growth factors. To investigate the possible involvement of other… CONTINUE READING

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