In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses.

@article{Co2009InVE,
  title={In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses.},
  author={Mary Dawn T Co and Laura Orphin and John Cruz and Pamela Pazoles and Karin M. Green and James N. Potts and Anita M. Leporati and Jenny Aurielle B Babon and James E Evans and Francis A. Ennis and Masanori Terajima},
  journal={Vaccine},
  year={2009},
  volume={27 2},
  pages={319-27}
}
We evaluated three commercial trivalent inactivated vaccines (TIVs) from the 2007-2008 season in terms of their ability to elicit in vitro T cell responses. T cell-mediated immunity may offer a more cross-reactive vaccine approach for the prevention of pandemic or epidemic influenza. Human cytotoxic T cell lines demonstrated differences in matrix protein 1 and nucleocapsid protein recognition of autologous target cells. Peripheral blood mononuclear cells stimulated with each of the TIVs showed… CONTINUE READING
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