In vitro evaluation ofPyrularia thionin—anti-CD5 immunotoxin


The membrane-active peptide,Pyrularia thionin, purified fromPyrularia pubera, was covalently conjugated to an anti-CD5 monoclonal antibody. The membrane-active properties of thionin were not affected by the conjugation. The immunotoxin killed CD5+ lymphocytes in vitro at a concentration of 0.1 nmol/107 cells after 2 h of incubation. The immunotoxin also… (More)
DOI: 10.1007/BF01527408


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