In vitro evaluation of tigecycline and comparative agents in 3049 clinical isolates: 2001 to 2002.

Abstract

Tigecycline is the first glycylcycline antimicrobial in phase III clinical trials. This study compares the in vitro activity of tigecycline to 12 other predominately broad-spectrum antimicrobials against 3049 recent inpatient isolates from 38 clinical centers in 17 countries. The minimum concentration at which tigecycline inhibited 90% of the isolates for the entire collection, excluding Pseudomonas aeruginosa, was 1 microg/mL, including vancomycin-resistant enterococci-, extended-spectrum beta-lactamase-, and methicillin-resistant Staphylococcus aureus-resistant phenotypes.

Cite this paper

@article{Bouchillon2005InVE, title={In vitro evaluation of tigecycline and comparative agents in 3049 clinical isolates: 2001 to 2002.}, author={Samuel K Bouchillon and Daryl J. Hoban and Brian M Johnson and Tim M Stevens and Michael Joseph Dowzicky and David P H Wu and Patricia A Bradford}, journal={Diagnostic microbiology and infectious disease}, year={2005}, volume={51 4}, pages={291-5} }