In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids.

@article{Eriksson2012InvitroEO,
  title={In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids.},
  author={Andr{\'e} Eriksson and Nina R{\o}nsted and Semiha G{\"u}ler and Anna K J{\"a}ger and J{\'u}lia Rodr{\'i}guez Sendra and Birger Brodin},
  journal={The Journal of pharmacy and pharmacology},
  year={2012},
  volume={64 11},
  pages={
          1667-77
        }
}
OBJECTIVES Drug compounds interacting with the blood-brain barrier efflux transporter P-glycoprotein (P-gp) might have limited access to brain tissue. The aim of the present study was to evaluate whether nine potentially CNS-active Amaryllidaceae alkaloids of the crinine, lycorine and galanthamine types interact with P-gp. METHODS Alkaloids with inhibitory activity towards either the serotonin reuptake transporter or acetylcholinesterase, or both, were investigated using the calcein-AM efflux… CONTINUE READING
BETA