In vitro evaluation of natural and methylated cyclodextrins as buccal permeation enhancing system for omeprazole delivery.

@article{Figueiras2009InVE,
  title={In vitro evaluation of natural and methylated cyclodextrins as buccal permeation enhancing system for omeprazole delivery.},
  author={Ana Figueiras and Juliane M R Hombach and F. Alte da Veiga and Andreas Bernkop-Schn{\"u}rch},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2009},
  volume={71 2},
  pages={339-45}
}
In this work the enhancing effect of cyclodextrins on the buccal permeation of a hydrophobic model drug, omeprazole was studied. First, the influence of the complexation with cyclodextrins in the absence and in the presence of an alkali agent, L-arginine, on the drug stability was checked at neutral conditions since omeprazole alone is only stable in basic… CONTINUE READING