In vitro evaluation of biodegradable epsilon-caprolactone-co-D, L-lactide/silica xerogel composites containing toremifene citrate.

@article{Ahola1999InVE,
  title={In vitro evaluation of biodegradable epsilon-caprolactone-co-D, L-lactide/silica xerogel composites containing toremifene citrate.},
  author={Manja Ahola and Jaana Rich and Pirjo Kortesuo and Juha Kiesvaara and Jukka Sepp{\"a}l{\"a} and Antti Yli-Urpo},
  journal={International journal of pharmaceutics},
  year={1999},
  volume={181 2},
  pages={181-91}
}
Poly(epsilon-caprolactone-co-D,L-lactide) polymers were blended with toremifene citrate or with toremifene citrate impregnated silica xerogel in order to develop a controlled release formulation. The copolymers were synthesized by bulk polymerization and characterized by nuclear magnetic resonance, size exclusion chromatography and differential scanning calorimetry analyses. The in vitro release of toremifene citrate, an antiestrogenic compound, and silica was carried out in simulated body… CONTINUE READING