In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay

@inproceedings{Sipinen2010InVE,
  title={In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay},
  author={Ville Sipinen and Julian Laubenthal and Adolf Baumgartner and Eduard Cemeli and Joost O Linschooten and Roger W L Godschalk and Frederik-Jan van Schooten and Diana Anderson and Gunnar Brunborg},
  booktitle={Mutagenesis},
  year={2010}
}
Exposure to genotoxins may compromise DNA integrity in male reproductive cells, putting future progeny at risk for developmental defects and diseases. To study the usefulness of sperm DNA damage as a biomarker for genotoxic exposure, we have investigated cellular and molecular changes induced by benzo[a]pyrene (B[a]P) in human sperm in vitro, and results have been compared for smokers and non-smokers. Sperm DNA obtained from five smokers was indeed more fragmented than sperm of six non-smokers… CONTINUE READING

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