In vitro evaluation of a novel orally administered cephalosporin (Cefditoren) tested against 1249 recent clinical isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae.

@article{Jones1998InVE,
  title={In vitro evaluation of a novel orally administered cephalosporin (Cefditoren) tested against 1249 recent clinical isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae.},
  author={R. N. Jones and Douglas J. Biedenbach and M. A. T. Croco and Mary S. Barrett},
  journal={Diagnostic microbiology and infectious disease},
  year={1998},
  volume={31 4},
  pages={
          573-8
        }
}
In Vitro Activity of Oral Cephalosporins against Pediatric Isolates of Streptococcus pneumoniae Non-Susceptible to Penicillin, Amoxicillin or Erythromycin
TLDR
Full resistance to penicillin or amoxicillin implied lack of susceptibility to all oral cephalosporins with defined CLSI breakpoints, rendering them inadequate as empirical treatment in countries with a high prevalence ofPenicillin resistance.
Antibiotic Susceptibility of Respiratory Pathogens Recently Isolated in Italy: Focus on Cefditoren
TLDR
Cefditoren's wide spectrum and high intrinsic activity, as well as its capacity to overcome most of the resistance that has become consolidated in some classes of antibiotics widely used as empiric therapy for CARTI, allows it to be suggested that cefditore might be included in the european guidelines as one of the first-choice antibiotics in the treatment of C ARTI.
Influence of penicillin/amoxicillin non-susceptibility on the activity of third-generation cephalosporins against Streptococcus pneumoniae
TLDR
The activity of cefixime, cefdinir and cefpodoxime was highly affected by penicillin/amoxicillin non-susceptibility, while parenteral third-generation cephalosporins exhibited higher intrinsic activity.
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TLDR
The MICs of RPR 106972, cefditoren, two new oxazolidinones, and other oral and parenteral agents for 203 penicillin-susceptible and -resistant pneumococci were determined.
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Beta-lactam agents included in the first group could be an acceptable alternative in the treatment of serious infections due to strains highly resistant to penicillin, although clinical experience is needed.
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TLDR
Investigation of the effect of laboratory variables on the in vitro activity of cefditoren indicates that it will present no special problems when tested in the clinical setting against bacterial pathogens.
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TLDR
Cefditoren and WY-49605 had the lowest MICs and most favourable time-kill kinetics of all beta-lactams tested and Cefuroxime and cefpodoxime were the most active of other oral cephalosporins tested.
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In vitro activities of eight macrolide antibiotics and RP-59500 (quinupristin-dalfopristin) against viridans group streptococci isolated from blood of neutropenic cancer patients
TLDR
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