In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications.

@article{Reubi2000InVE,
  title={In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications.},
  author={Jean Claude Reubi},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={921},
  pages={1-25}
}
The evaluation of peptide receptors in man is relevant to identifying the physiological target tissues of a given peptide and to selecting diseases with a sufficient receptor overexpression for diagnostic or therapeutic intervention. VIP/PACAP receptors have been evaluated in normal and diseased human non-neuronal tissues by using in vitro receptor autoradiography with 125I-VIP or 125I-PACAP in tissue sections. As assessed by subtype-selective VIP analogs, VIP receptors of the VPAC1 subtype are… CONTINUE READING

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