In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes.

@article{Caspi2009InVE,
  title={In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes.},
  author={Oren Caspi and Ilanit Itzhaki and Izhak Kehat and Amira Gepstein and Gil Arbel and Irit Huber and Jonathan Satin and Lior Gepstein},
  journal={Stem cells and development},
  year={2009},
  volume={18 1},
  pages={161-72}
}
Pro-arrhythmia (development of cardiac arrhythmias as a pharmacological side effect) has become the single most common cause of the withdrawal or restrictions of previously marketed drugs. The development of new medications, free from these side effects, is hampered by the lack of an in vitro assay for human cardiac tissue. We hypothesized that human embryonic stem cell-derived cardiomyocytes (hESC-CMs) assessed with a combination of single cell electrophysiology and microelectrode array (MEA… CONTINUE READING