In vitro efficiency of the piperacillin/tazobactam combination against inhibitor-resistant TEM- and complex mutant TEM-producing clinical strains of Escherichia coli.

@article{Robin2011InVE,
  title={In vitro efficiency of the piperacillin/tazobactam combination against inhibitor-resistant TEM- and complex mutant TEM-producing clinical strains of Escherichia coli.},
  author={Fr{\'e}d{\'e}ric Robin and Marion Krebs and Julien Delmas and Lucie Gibold and Caroline Mirande and R. Bonnet},
  journal={The Journal of antimicrobial chemotherapy},
  year={2011},
  volume={66 5},
  pages={1052-6}
}
OBJECTIVES We investigated the bacteriostatic and bactericidal activities of piperacillin/tazobactam against 16 clinical Escherichia coli producing inhibitor-resistant TEM β-lactamases (IRT; 13/16) and complex mutant TEM enzymes (CMT; 3/16). METHODS Bacteriostatic activity was evaluated by three methods (disc diffusion, Vitek2 automated system, MIC determination by a microdilution method) and a time-killing study was used to investigate the bactericidal effect against standard (5 × 10(5) cfu… CONTINUE READING

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Breakpoint tables for interpretation of MICs and zone diameters

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