In vitro efficacies of caspofungin or micafungin catheter lock solutions on Candida albicans biofilm growth.

  title={In vitro efficacies of caspofungin or micafungin catheter lock solutions on Candida albicans biofilm growth.},
  author={Estelle Cateau and Marie-H{\'e}l{\`e}ne Rodier and Christine Imbert},
  journal={The Journal of antimicrobial chemotherapy},
  volume={62 1},
OBJECTIVES Caspofungin and micafungin belong to the echinocandins; the mechanism of action of echinocandins is based on the inhibition of (1,3)-beta-D-glucan synthase. The aim of this study was to investigate in vitro the optimal antifungal lock treatment details against a Candida albicans biofilm. METHODS An in vitro model of a C. albicans (ATCC 3153 or ATCC 66396) biofilm associated with 100% silicone catheters was used. The effectiveness of the antifungal treatment was assayed against… 

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