In vitro effects on DNA synthesis as a predictor of biological effect from chemotherapy.

@article{Livingston1980InVE,
  title={In vitro effects on DNA synthesis as a predictor of biological effect from chemotherapy.},
  author={Robert B. Livingston and G A Titus and Lance K. Heilbrun},
  journal={Cancer research},
  year={1980},
  volume={40 7},
  pages={2209-12}
}
Cell suspensions of tumor or normal bone marrow were incubated in vitro with control media (supplemented Ham's F-10 medium or autologous, pretreatment plasma) and with autologous, posttreatment plasma containing chemotherapeutic agents or their metabolites (treated plasma). Drug-specific perturbation of tumor cell DNA synthesis, as measured by the thymidine labeling index, occurred in treated plasma in 9 of 9 courses where antitumor effect was seen compared to 2 of 8 in which chemotherapy… CONTINUE READING

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