In vitro effects of the new calcium antagonist lacidipine.

  title={In vitro effects of the new calcium antagonist lacidipine.},
  author={T. Kawada and H. T. Sun and M. Nakazawa and S. Imai},
  journal={Japanese journal of pharmacology},
  volume={62 3},
The effects of lacidipine (LC), a new dihydropyridine calcium antagonist, were studied in comparison with those of nifedipine (NF) in isolated arteries of the dog (DG-AR) and isolated aorta (GP-AO), left and right atria (GP-LA, GP-RA) and ventricular papillary muscles (GP-PM) of the guinea pig. In DG-AR precontracted with high K+, LC and NF produced a concentration-dependent relaxation. The relaxant effect of LC was most potent in the basilar artery. The calcium antagonistic effects of LC was 8… Expand
6 Citations
Effects of a calcium antagonist, lacidipine, on experimental focal cerebral ischemia in rats.
The results suggest that the improvement of focal cerebral ischemia by lacidipine may be partly due to long-lasting improvement of collateral blood supply to the ischemic area. Expand
Vasorelaxant and antihypertensive effects of ZCM298, a dihydropyridine derivative, are through inhibiting extracellular calcium influx.
ZCM298 relaxes arteries probably through inhibiting extracellular calcium influx and decreases the blood pressure of SHRs and is more potent in the basilar artery than in the mesenteric artery and improves rCBF in the pia mater of rats. Expand
Lacidipine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of hypertension.
Lacidipine is an orally administered calcium channel blocker of the dihydropyridine class, which shows selectivity for vascular smooth muscle over cardiac tissue and has a long duration of action. InExpand
Therapeutic effects of a calcium antagonist, lacidipine, on stroke-prone spontaneously hypertensive rats with cerebrovascular lesions.
It is suggested that a long-lasting improvement of low-rBF after stroke may be useful in the treatment of SHRSP with cerebrovascular lesions, and lacidipine at 1 mg/kg alone ameliorated the cerebral low- rBF significantly even at 24 hr after administration. Expand
Calcium Ion Channels and Their Blockers
Calcium is a ubiquitous second messenger. Calcium entry into the cytosol is mediated by multiple types of calcium channels each with a distinct physiological role. There exist five different types ofExpand
Ion channels and their inhibitors
Structural and Functional Discrimination of Membrane.- Proteins.- Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.- Advanced Molecular Modeling Techniques AppliedExpand


Pharmacology of Lacidipine, a Vascular‐Selective Calcium Antagonist
The marked vascular selectivity of lacidipine was clearly evident both in pithed rats infused with angiotensin II and in anesthetized dogs, in which preferential and long-lasting coronary and vertebral blood flow increases were also observed. Expand
Lacidipine: A Calcium Antagonist with Potent and Long‐Lasting Antihypertensive Effects in Animal Studies
In spontaneously hypertensive rats (SHR), lacidipine proved –30 times more potent, slower in onset, and longer-acting than nitrendipine in reducing blood pressure, and induced a natriuretic effect in saline-loaded SHR at antihypertensive doses. Expand
Cardiac Electrophysiologic Effects of a New Calcium Antagonist, Lacidipine
The results indicate that lacidipine has calcium-antagonistic properties in cardiac tissues, and its cardiac effects occur at concentrations 100 times higher than those active in the vascular smooth muscle. Expand
Cardiac versus vascular effects of a new dihydropyridine derivative, CV-4093. In vitro comparison with other calcium antagonists.
The results suggest that CV-4093 is a calcium antagonist with a highly selective vascular effect and little cardiodepressant action, and could be of value for the treatment of hypertension. Expand
A comparative in vitro study of transdermal absorption of a series of calcium channel antagonists.
The in vitro transdermal absorption of five calcium channel antagonists was studied using the skin of hairless rats as a membrane to determine the penetration parameters [permeability constant (Kp), lag time (T1, and flux) and predict the potential capacity of these drugs to be formulated in a therapeutical transDermal system (TTS). Expand
Differences Between Dihydropyridine and Non-Dihydropyridine Calcium Antagonists in Inotropic, Chronotropic, Dromotropic and Vascular Effects: Differences in Underlying Mechanism
It is generally accepted that nifedipine and nicardipine, dihydropyridine (DHP) calcium antagonists (Ca-antagonists), are less cardiodepressant that verapamil and diltiazem, non-dihydropyridineExpand
Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker.
The blood pressure lowering effects of CS-905 was most potent in DOCA-salt hypertensive rats, followed by SHR, RHR and normotensive Rats, in this order. Expand
Selective abolition of Ca-dependent responses of smooth and cardiac muscles by flunarizine.
The experiments indicate that flunarizine is selective in antagonizing Ca-dependent contraction of the rabbit basilar artery, probably by blockade of the transmembrane Ca. Expand
Functional Interaction of Lacidipine with Calcium Channels in Vascular Smooth Muscle
It is concluded that lacidipine inhibits rat aorta contraction by interacting specifically with voltage‐operated Ca2+ channels. Expand
Effects of calcium-antagonistic coronary vasodilators on myocardial contractility and membrane potentials.
  • H. Nabata
  • Chemistry, Medicine
  • Japanese journal of pharmacology
  • 1977
The effects of nifedipine, verapamil and diltiazem on isolated electrically-driven left atrial preparations of the guinea pig were studied and calcium-dependent action potentials were evoked in the potassium-depolarized atria either by isoproterenol or aminophylline. Expand