In vitro effects of recombinant chicken interferon-gamma on immune cells.

@article{Yeh1999InVE,
  title={In vitro effects of recombinant chicken interferon-gamma on immune cells.},
  author={Heidi Yeh and Barbara J. Winslow and David E. Junker and Jagdev M Sharma},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={1999},
  volume={19 6},
  pages={
          687-91
        }
}
We used the recombinant chicken interferon-gamma (ChIFN-gamma) to determine its in vitro effects on chicken immune cells. We found that ChIFN-gamma induced nitric oxide (NO) production, upregulated Ia expression on the cell surface, and inhibited the replication of Newcastle disease virus in NCSU and HD11 cells (chicken macrophage cell lines). In addition, ChIFN-gamma had an antiproliferative effect on RP9 cells, a chicken B cell line. Finally, ChIFN-gamma inhibited mitogenic proliferation of… CONTINUE READING
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