In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.

@article{Cormier2001InVE,
  title={In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.},
  author={A D Cormier and Christopher Morin and Roland Zini and J. P. Tillement and Gilbert Lagrue},
  journal={Brain research},
  year={2001},
  volume={900 1},
  pages={72-9}
}
In this study, we investigated the effects of nicotine on rat brain mitochondria. The polarographic studies determined the effects on the respiratory chain, whereas enzymatic assays and [3H]-nicotine binding allowed us to precisely identify its target and site of action. The measurements of oxygen consumption showed a significantly concentration-dependent inhibition by nicotine (EC50 was 4.95x10(-11) M), and a maximal decrease of 23.90% at 10(-7) M. Nicotine bound to complex I of the… CONTINUE READING
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