In vitro effects of meloxicam with or without doxorubicin on canine osteosarcoma cells.

@article{Wolfesberger2006InVE,
  title={In vitro effects of meloxicam with or without doxorubicin on canine osteosarcoma cells.},
  author={Birgitt Wolfesberger and Claudia Hoelzl and Ingrid Walter and Georg A Reider and G Fertl and Johann G. Thalhammer and Monika Skalicky and Monika Egerbacher},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2006},
  volume={29 1},
  pages={15-23}
}
Cyclooxygenase (COX) inhibitors, already widely used to reduce fever, inflammation and pain, are under increasing consideration as potential agents for the prevention and treatment of neoplasia. As COX-2 was detected in human and canine osteosarcomas, we have evaluated the effect of the preferential COX-2 inhibitor meloxicam on an established D-17 canine osteosarcoma cell line, which expressed, as well as COX-1 and COX-2 also COX-3 (as demonstrated by Western blot). An XTT proliferation kit was… CONTINUE READING

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