In vitro effects of carbutamide and tolbutamide on isolated frog muscle.

@article{Gourley1958InVE,
  title={In vitro effects of carbutamide and tolbutamide on isolated frog muscle.},
  author={D. R. H. Gourley and Robert H. Dodd},
  journal={The American journal of physiology},
  year={1958},
  volume={192 3},
  pages={
          471-5
        }
}
  • D. Gourley, R. Dodd
  • Published 28 February 1958
  • Biology, Chemistry
  • The American journal of physiology
Carbutamide and tolbutamide, sulfonylurea compounds which reduce the blood glucose concentration in intact animals, do not act like insulin in isolated frog muscle. Carbutamide, like sulfanilamide, inhibits the consumption of oxygen and increases the loss of potassium from the muscle. Tolbutamide greatly increases the oxygen consumption and decreases the loss of potassium from the tissue. These effects of tolbutamide are accompanied by a loss of muscle glycogen and an accumulation of lactate… 
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