In vitro effects of bone- and platelet-derived transforming growth factor-β on the growth of Walker 256 carcinosarcoma cells

@article{MillarBook1990InVE,
  title={In vitro effects of bone- and platelet-derived transforming growth factor-β on the growth of Walker 256 carcinosarcoma cells},
  author={W. Millar-Book and F. William Orr and Gurmit Singh},
  journal={Clinical & Experimental Metastasis},
  year={1990},
  volume={8},
  pages={503-510}
}
Conditioned media from fetal rat calvarial cultures has previously been shown to stimulate the growth of the bone-metastasizing Walker 256 carcinosarcoma cell line. In the current investigation we looked at the possibility that transforming growth factor-β (TGF-β), present in conditioned media, and positively correlated with resorption in vitro, may be responsible for the enhanced proliferation of Walker cells cultured in these conditioned media. Purified platelet-derived TGF-β produced a dose… CONTINUE READING