In vitro effects of bisphenol A on developing hypothalamic neurons.

@article{Iwakura2010InVE,
  title={In vitro effects of bisphenol A on developing hypothalamic neurons.},
  author={Takashi Iwakura and Makiko Iwafuchi and Daisuke Muraoka and Makoto Yokosuka and Takashi Shiga and Chiho Watanabe and Ritsuko Ohtani-kaneko},
  journal={Toxicology},
  year={2010},
  volume={272 1-3},
  pages={
          52-8
        }
}
Estradiol plays an essential role in sexual differentiation of the rodent hypothalamus. Endocrine disruptors with estrogenic activity such as bisphenol A (BPA) are reported to disturb sexual differentiation of the hypothalamus. The purpose of the present study was to examine in vitro effects of BPA on developing hypothalamic neurons by focusing on a presynaptic protein synapsin I and microtubule-associated protein 2 (MAP2). In cultured hypothalamic cells from fetal rats, treatment with BPA… CONTINUE READING

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