In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators

@article{Henrotin2001InVE,
  title={In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators},
  author={Yves Edgard Henrotin and Xavier de Leval and M. Mathy-Hartet and Ange L Mouithys-Mickalad and G Deby-dupont and J.-M. Dogn{\'e} and Jacques Delarge and J. Y. L. Reginster},
  journal={Inflammation Research},
  year={2001},
  volume={50},
  pages={391-399}
}
Objectives: To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4′-hydroxyaceclofenac, in comparison with diclofenac, another metabolite, on cyclooxygenases activity as well as interleukin-1β, -6 and -8, nitric oxide, and prostaglandin… CONTINUE READING