In vitro effect of plasmin on human platelet function in plasma. Inhibition of aggregation caused by fibrinogenolysis.

@article{Gouin1992InVE,
  title={In vitro effect of plasmin on human platelet function in plasma. Inhibition of aggregation caused by fibrinogenolysis.},
  author={Isabelle Gouin and Thomas Pierre Lecompte and M C Morel and J Lebrazi and Piet W. Modderman and C. Kaplan and Meyer Michel Samama},
  journal={Circulation},
  year={1992},
  volume={85 3},
  pages={935-41}
}
BACKGROUND Plasmin has been reported both to activate platelets and to inhibit platelet functions. The latter effect was thought to be caused by proteolysis of the main membrane glycoproteins. METHODS AND RESULTS We found that incubation of citrated human platelet-rich plasma with streptokinase (SK) (300 IU/ml) does not produce any detectable activation but leads to a time-dependent inhibition of ADP-induced aggregation accompanied by substantial fibrinogenolysis. These effects were abrogated… CONTINUE READING
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Streptoki - nase - induced platelet aggregation : Prevalence and mechanism

  • DE Vaughan, E VanHoutte, PJ Declerck, D Collen
  • Circulation
  • 1991

Effects of plasmin on human platelets : Activation and inhibition of aggregation ( abstract )

  • I Gouin, T Lecompte, MC Morel, F Potevin, C Kaplan, M Samama
  • Fibrinolysis
  • 1990

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