In vitro effect of chromium and other trace metals on mouse hepatotoxicity induced by carbon tetrachloride exposure.

@article{Tezuka1995InVE,
  title={In vitro effect of chromium and other trace metals on mouse hepatotoxicity induced by carbon tetrachloride exposure.},
  author={Masakatsu Tezuka and S Sadanobu and Kiyoshi Gomi and Mariko Tachikawa and Ryoji Sawamura},
  journal={Biological \& pharmaceutical bulletin},
  year={1995},
  volume={18 2},
  pages={
          256-61
        }
}
Using primary cultured mouse hepatocytes, in vitro study was performed to discuss the effect of Cr(III) and several other trace metals, Cr(VI), Mn(II), Zn(II), Co(II), Cu(II), Ni(II), and Ga(III) on acute liver damage induced by CCl4 exposure. 1) The LDH activity 60 min after CCl4 exposure increased dose-dependently with CCl4 concentrations in all of the trace metal pretreatment groups, except for the Cr(VI) pretreatment group, which showed a significant protective effect even after 30 min of… 
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A trial on the quantitative risk assessment of man-made mineral fibers by the rat intraperitoneal administration assay using the JFM standard fibrous samples using theJFM standard Fibrous samples shows good results.