In vitro drug metabolism using liver microsomes.

@article{Hill2004InVD,
  title={In vitro drug metabolism using liver microsomes.},
  author={Jeanette R Hill},
  journal={Current protocols in pharmacology},
  year={2004},
  volume={Chapter 7},
  pages={
          Unit7.8
        }
}
Metabolic biotransformation of a drug can increase the rate of elimination from the body and have a significant effect on efficacy and safety. Drug candidates are screened early in the discovery process for metabolic stability using liver microsomes. Methods for microsome isolation and characterization and the determination of metabolic stability are presented. 
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