In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells

@article{Leonquinto2004InVD,
  title={In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells},
  author={T Leon-quinto and Jonathan Jones and Anouchka L Skoudy and Mark Burcin and Bernat Soria},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={1442-1451}
}
We recently demonstrated that insulin-producing cells derived from embryonic stem cells normalise hyperglycaemia in transplanted diabetic mice. The differentiation and selection procedure, however, was successful in less than 5% of the assays performed. Thus, to improve its effectiveness, new strategies have been developed, which increase the number of islet cells or islet progenitors. Mouse embryonic stem cells transfected with a plasmid containing the Nkx6.1 promoter gene followed by a… CONTINUE READING
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From the cover: effects of eight growth factors on the differentiation of cells

  • M Schuldiner, O Yanuka, J Itskovitz-Eldor, D Melton, N Benvenitsy
  • J Biol Chem
  • 2000
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