In vitro differentiation of a CD4/CD8 double-positive equivalent thymocyte subset in adult Xenopus.

Abstract

The thymus is the major site of selection and differentiation of T cells in mammals and birds. To begin to study the evolution of thymocyte differentiation, we have developed, in the frog Xenopus, an in vitro system that takes advantage of cortical thymocyte antigen (CTX), a recently discovered T cell antigen whose expression is restricted to Xenopus… (More)

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