In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice.

@article{Nayernia2006InVE,
  title={In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice.},
  author={Karim Nayernia and Jessica Nolte and Hans Wilhelm Michelmann and Jae Ho Lee and Kristina Rathsack and Nadja Drusenheimer and Arvind A. Dev and Gerald G. Wulf and Ingrid E Ehrmann and David J. Elliott and Vera Okpanyi and Ulrich Zechner and Thomas Haaf and Andreas Meinhardt and Wolfgang Engel},
  journal={Developmental cell},
  year={2006},
  volume={11 1},
  pages={125-32}
}
Male gametes originate from a small population of spermatogonial stem cells (SSCs). These cells are believed to divide infinitely and to support spermatogenesis throughout life in the male. Here, we developed a strategy for the establishment of SSC lines from embryonic stem (ES) cells. These cells are able to undergo meiosis, are able to generate haploid male gametes in vitro, and are functional, as shown by fertilization after intracytoplasmic injection into mouse oocytes. Resulting two-cell… CONTINUE READING
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