In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles.

@article{Park2009InVD,
  title={In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles.},
  author={Margriet V D Z Park and Wijtske Annema and Anna Salvati and Anna Leśniak and Andreas Elsaesser and Clifford A Barnes and George McKerr and C. Vyvyan Howard and Iseult Lynch and Kenneth A. Dawson and Aldert H. Piersma and Wim H De Jong},
  journal={Toxicology and applied pharmacology},
  year={2009},
  volume={240 1},
  pages={108-16}
}
While research into the potential toxic properties of nanomaterials is now increasing, the area of developmental toxicity has remained relatively uninvestigated. The embryonic stem cell test is an in vitro screening assay used to investigate the embryotoxic potential of chemicals by determining their ability to inhibit differentiation of embryonic stem cells into spontaneously contracting cardiomyocytes. Four well characterized silica nanoparticles of various sizes were used to investigate… CONTINUE READING

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