In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus.

@article{Boos2001InVD,
  title={In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus.},
  author={Mechthild Boos and Susanne V Mayer and Arno Fischer and Karl K{\"o}hrer and Sibylle Scheuring and Peter Heisig and J. C. Barendrecht Verhoef and Ad C. Fluit and F. J. Schmitz},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 3},
  pages={938-42}
}
Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus isolates were exposed to subinhibitory MICs of ciprofloxacin, sparfloxacin, gatifloxacin, moxifloxacin, clinafloxacin, and gemifloxacin during a 10-day period. Subculturing led to resistance development, regardless of the initial potencies of the quinolones. None of the quinolones was associated with a significantly slower rate of resistance development.