In vitro development of resistance to five quinolones and amoxicillin-clavulanate in Streptococcus pneumoniae.

@article{Davies1999InVD,
  title={In vitro development of resistance to five quinolones and amoxicillin-clavulanate in Streptococcus pneumoniae.},
  author={Todd A Davies and Glenn A. Pankuch and Bonifacio E Dewasse and Michael R. Jacobs and Peter C. Appelbaum},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 5},
  pages={1177-82}
}
The ability of 50 sequential subcultures in subinhibitory concentrations of ciprofloxacin, levofloxacin, grepafloxacin, sparfloxacin, trovafloxacin, and amoxicillin-clavulanate to select for resistance was studied for six penicillin-susceptible and four penicillin-intermediate pneumococci. Subculturing in ciprofloxacin, grepafloxacin, levofloxacin, and sparfloxacin led to selection of mutants requiring increased MICs for all 10 strains, with MICs rising from (i) 0.5 to 4.0 to (ii) 4.0 to 32.0… CONTINUE READING

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