In vitro development of hematopoietic system from mouse embryonic stem cells: a new approach for embryonic hematopoiesis.

@article{Nakano1996InVD,
  title={In vitro development of hematopoietic system from mouse embryonic stem cells: a new approach for embryonic hematopoiesis.},
  author={Toru Nakano},
  journal={International journal of hematology},
  year={1996},
  volume={65 1},
  pages={1-8}
}
  • Toru Nakano
  • Published 1996 in International journal of hematology
We developed an efficient differentiation induction system (OP9 system) from mouse embryonic stem (ES) cell to blood cells by coculture on a novel stromal cell line, OP9. This stromal cell line does not produce functional macrophage colony-stimulating factor (M-CSF) and presumably the deficiency of M-CSF production of OP9 cells might induce preferential differentiation of ES cells into hematopoietic cells other than the monocyte-macrophage lineage. ES cells gave rise to embryonic primitive… CONTINUE READING
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