In vitro determination of the mechanism of the uterine stimulatory effect of Newbouldia laevis

  title={In vitro determination of the mechanism of the uterine stimulatory effect of Newbouldia laevis},
  author={Enitome Evi Bafor and U. Sanni and Zuleikha A. M. Nworgu},
  journal={Pharmaceutical Biology},
  pages={808 - 815}
The uterine stimulatory effect of the ethanol leaf extract of Newbouldia laevis (Beauv.) Seemann ex Bureau (Bignoniaceae) was evaluated in the presence of some antagonists in vitro in an attempt to elucidate the mechanism of action of the extract. The extract was tested in the presence and absence of phentolamine (4.09 and 40.91 nM), diphenhydramine (4.45 and 44.47 nM), atropine (1.18 and 11.91 nM), and verapamil (2.03 and 20.35 nM). The effect of the antagonists on the extract and on oxytocin… 
Biochemical and Haematological Effects of the Leaf Extract of Newbouldia laevis in Alloxan-Induced Diabetic Rats
Administration of DME has significant ameliorative effect on alloxan-induced anaemia and other haematological alterations in diabetes and this may be of immense benefits in the management of diabetes and its associated haem atological complications.
Aqueous Extract of Newbouldia laevis Abrogates Cadmium-Induced Ovarian Dysfunction in Adult Wistar Rats
Investigation of the ameliorative effect of Newbouldia laevis in cadmiuminduced ovarian dysfunction demonstrates that administration of aqueous extract of N. laevIS during treatment with Cadmium sulphate preserves ovarian function, suggesting that possibly daily intake of a Quebec-based extracts prevents the onset of ovarian disorders.
Antihyperglycemic Studies on the Leaf Extract and Active Fractions of Newbouldia laevis (Bignoniaceae)
Newbouldia Laevis possess antihyperglycemic activities and can be the basis for the folk use N. laevis in management of diabetes mellitus.
Trado-Medical uses, Chemical Constituents and Biological Activities of Newbouldia laevis (Bignoniaceae): A Review
This review discusses the trado-medical uses, chemical constituents, and biological activities of N. laevis and lends credence to the ethnobotanical uses of the plant in folkloric practice.


Phytochemical and in vitro antimicrobial assay of the leaf extract of Newbouldia laevis.
  • H. Usman, J. Osuji
  • Medicine, Biology
    African journal of traditional, complementary, and alternative medicines : AJTCAM
  • 2007
The traditional use of this plant is justified for the treatment of stomach discomfort, diarrhea, dysentery and as a remedy for wound healing whose causative agents are some of the organisms used in this study.
Pharmacological actions of tannic acid. I. Effects on isolated smooth and cardiac muscles and on blood pressure.
The results suggest that tannic acid can affect calcium availability for contraction of smooth and cardiac muscles, and this action could well mask the effects of other active constituents of tanno-rich plant extracts.
History and use of oxytocics.
  • P. Norris
  • Medicine
    The Journal of obstetrics and gynaecology of the British Empire
  • 1961
By showing that drugs used specifically for their action on the heart also have a profound influence on the uterus, the lecturer hopes to pay tribute to the first President of the authors' College.
A comparison of the central and peripheral effects of atropine, scopolamine and some synthetic atropine-like compounds.
The data on central anti-acetylcholine action of such agents are scrutinized and it now appears that the evidence for such effects is circumstantial.
Agonist and antagonist specificities of decidual prostaglandin-releasing oxytocin receptors and myometrial uterotonic oxytocin receptors in pregnant rats.
It was found that the decidual and myometrial oxytocin receptors exhibit different ligand specificities and arginine-vasopressin was found to have 16% of its PGF2 alpha-releasing activity.
Identification and preliminary phytochemical analysis of herbs that can arrest threatened miscarriage in Orba and Nsukka towns of Enugu State
The preliminary phytochemical analysis detected the presence of carbohydrate, reducing sugar, alkaloids, glycoside, saponins, tannins, flavonoids, resin, proteins, oil, steroids, terpenoids and acidic compounds.
Inhibition of signal-regulated protein kinases by plant-derived hydrolysable tannins.
Medicinal herbs used for managing some common ailments among Esan people of Edo State, Nigeria.
It can be concluded that medicinal herbs have played and will continue to play major roles in the management of commo n diseases in these communities.