In vitro desensitization of isolated nephron segments to vasopressin.

  title={In vitro desensitization of isolated nephron segments to vasopressin.},
  author={Isabelle Dublineau and Philippe Pradelles and Christian de Rouffignac and Jean-Marc Elalouf},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={87 19},
Recent studies have demonstrated that in vivo administration of 1-deamino-8-D-arginine-vasopressin, an analog of arginine-8-vasopressin, induces homologous desensitization to vasopressin in the thick ascending limb of the loop of Henle. Desensitization has been documented by a decreased physiological response to vasopressin in vivo and by a reduced cAMP accumulation in the cortical thick ascending limb (CTAL). By measuring cAMP content in single isolated medullary thick ascending limbs (MTALs… CONTINUE READING