In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24.

@article{Taddese2009InVD,
  title={In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24.},
  author={Samuel Taddese and Anthony S Weiss and G{\"u}nther Jahreis and Reinhard H. H. Neubert and Christian E H Schmelzer},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2009},
  volume={28 2},
  pages={84-91}
}
Degradation of elastic fibers in tissues can result in the development of disorders that include aneurysms, atherosclerosis, and loss of skin elasticity. Tropoelastin is the precursor of the cross-linked elastin and its expression is triggered by elastin-degrading factors as a response to damage. Factors like UV radiation not only increase the expression of tropoelastin but also potent metalloelastases such as macrophage elastase (MMP-12). The development of elastin-degrading diseases, moreover… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs.

Matrix biology : journal of the International Society for Matrix Biology • 2017
View 2 Excerpts

Elastin sequences trigger transient proinflammatory responses by human dermal fibroblasts.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2013
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 52 references

PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry.

Rapid communications in mass spectrometry : RCM • 2003
View 2 Excerpts
Highly Influenced

Proteoglycans and pathophysiology.

Journal of applied physiology • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…