In vitro degradation of gastric mucin. Carbohydrate side chains protect polypeptide core from pancreatic proteases.

Abstract

The polypeptide core of mucin glycoprotein subunits resists cleavage by proteases. To determine if the carbohydrate side chains of these subunits protect the underlying polypeptide core from proteolytic cleavage, we compared the effect of pancreatic proteases on hog gastric mucin before and after cleavage of its carbohydrate moieties by bacterial… (More)

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