In vitro degradation of a poly(propylene fumarate)-based composite material.

  title={In vitro degradation of a poly(propylene fumarate)-based composite material.},
  author={Michael J. Yaszemski and Richard G Payne and Wilson C. Hayes and Robert S Langer and Antonios G Mikos},
  volume={17 22},
We investigated the in vitro degradation of a novel degradable polymeric composite material being developed to function as a temporary replacement for trabecular bone. This material is based on a mixture of poly(propylene fumarate) cross-linked by N-vinyl-pyrrolidone and includes sodium chloride and beta-tricalcium phosphate. Using an in vitro test in simulated body fluids, the compressive strengths and compressive moduli of two composite materials increased with degradation time and remained… CONTINUE READING
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