In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility.

@article{Brunner2006InVC,
  title={In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility.},
  author={Tobias Josef Brunner and Peter Wick and Pius Manser and Philipp Spohn and Robert N. Grass and Ludwig K Limbach and Arie Bruinink and Wendelin J Stark},
  journal={Environmental science & technology},
  year={2006},
  volume={40 14},
  pages={4374-81}
}
Early indicators for nanoparticle-derived adverse health effects should provide a relative measure for cytotoxicity of nanomaterials in comparison to existing toxicological data. We have therefore evaluated a human mesothelioma and a rodent fibroblast cell line for in vitro cytotoxicity tests using seven industrially important nanoparticles. Their response in terms of metabolic activity and cell proliferation of cultures exposed to 0-30 ppm nanoparticles (microg g(-1)) was compared to the… CONTINUE READING
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