In vitro cytotoxicity of Stealth liposomes co-encapsulating doxorubicin and verapamil on doxorubicin-resistant tumor cells.

@article{Wang2005InVC,
  title={In vitro cytotoxicity of Stealth liposomes co-encapsulating doxorubicin and verapamil on doxorubicin-resistant tumor cells.},
  author={J C Wang and BoonCher Goh and Wanliang Lu and Qiang Zhang and Alex Chang and Xiao Yan Liu and Theresa May Chin Tan and Howsung Lee},
  journal={Biological & pharmaceutical bulletin},
  year={2005},
  volume={28 5},
  pages={822-8}
}
Multidrug resistance (MDR) is a major obstacle to successful clinical cancer chemotherapy. A novel doxorubicin anti-resistant Stealth liposomes (DARSLs), prepared by co-encapsulating doxorubicin (DOX) and verapamil (VER) into stealth liposomes, has been developed. The average particle size of DARSLs was 118.1+/-22.3 nm. Encapsulation efficiencies of DOX and VER in DARSLs were greater than 95% and 70%, respectively. The IC(50) of DARSLs as measured by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl… CONTINUE READING
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