In vitro cytotoxicity of Mokko lactone in human leukemia HL-60 cells: induction of apoptotic cell death by mitochondrial membrane potential collapse.

@article{Yun2004InVC,
  title={In vitro cytotoxicity of Mokko lactone in human leukemia HL-60 cells: induction of apoptotic cell death by mitochondrial membrane potential collapse.},
  author={Y G Yun and Hyuncheol Oh and G S Oh and H O Pae and B M Choi and Ji Wung Kwon and Tae Oh Kwon and S I Jang and Hun Taeg Chung},
  journal={Immunopharmacology and immunotoxicology},
  year={2004},
  volume={26 3},
  pages={343-53}
}
We studied the effect of mokko lactone (ML) isolated from the roots of Saussurea lappa (Compositae), a plant that is used for medicinal purposes in Korea, on the induction of apoptosis in human leukemia HL-60 cells. ML was cytotoxic to HL-60 cells, and this cytotoxic effect of ML appears to be attributable to its induction of apoptotic cell death, as ML induced nuclear morphologic changes and internucleosomal DNA fragmentation and increased the proportion of Annexin V-positive cells and the… CONTINUE READING