In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line.

@article{Chang2007InVC,
  title={In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line.},
  author={Jenq-Sheng Chang and K. B. Chang and D F Hwang and Zwe-Ling Kong},
  journal={Environmental science & technology},
  year={2007},
  volume={41 6},
  pages={2064-8}
}
Amorphous silica is increasingly used in diagnostic and biomedical research because of its ease of production and relatively low cost. It is generally regarded as safe and has been approved for use as a food or animal feed ingredient. Recent literature reveals that amorphous silica may present toxicity concerns at high doses. In anticipation of potential human exposure to silica, it is advisable to examine its toxicity to cells of different organs. Consequently, we investigated the response of… CONTINUE READING

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