In vitro cytokine production and proliferation of T cells from patients with anti-proteinase 3- and antimyeloperoxidase-associated vasculitis, in response to proteinase 3 and myeloperoxidase.

@article{Popa2002InVC,
  title={In vitro cytokine production and proliferation of T cells from patients with anti-proteinase 3- and antimyeloperoxidase-associated vasculitis, in response to proteinase 3 and myeloperoxidase.},
  author={Eliane R. Popa and Casper F. M. Franssen and Pieter Coenraad Limburg and Minke G. Huitema and CeesG. M. Kallenberg and Jan Willem Cohen Tervaert},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 7},
  pages={
          1894-904
        }
}
OBJECTIVE To investigate in vitro proliferative responses of CD4+ T cells and generation of specific cytokines induced by stimulation of peripheral blood mononuclear cells (PBMCs) from patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis with the autoantigens proteinase 3 (PR3) and myeloperoxidase (MPO). METHODS PBMCs from vasculitis patients with PR3 ANCA or MPO ANCA and from healthy controls were stimulated for 7 days with PR3, MPO, or control stimuli… CONTINUE READING
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