In vitro cytocidal effect of novel lytic peptides on Plasmodium falciparum and Trypanosoma cruzi.

@article{Jaynes1988InVC,
  title={In vitro cytocidal effect of novel lytic peptides on Plasmodium falciparum and Trypanosoma cruzi.},
  author={Jesse M. Jaynes and Carolyn A. Burton and Stephanie B Barr and G W Jeffers and G R Julian and Kenneth L. White and Fred M Enright and Thomas R. Klei and Roger A Laine},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1988},
  volume={2 13},
  pages={2878-83}
}
Plasmodium falciparum and Trypanosoma cruzi were killed by two novel lytic peptides (SB-37 and Shiva-1) in vitro. Human erythrocytes infected with P. falciparum, and Vero cells infected with T. cruzi, were exposed to these peptides. The result, in both cases, was a significant decrease in the level of parasite infection. Furthermore, the peptides had a marked cytocidal effect on trypomastigote stages of T. cruzi in media, whereas host eukaryotic cells were unaffected by the treatments. In view… CONTINUE READING
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